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Research Article

Academia Journal of Scientific Research 6(11): 429-441, November 2018
DOI: 10.15413/ajsr.2018.0154
ISSN: 2315-7712
2018 Academia Publishing 

Abstract

 

 

EGFR: An important perspective in cancer therapy
 

Accepted 15th November, 2018

 
Shahare Hitesh V.1* and Talele Gokul. S.2

1Department of Pharmaceutical Chemistry, SNJBs Shriman Sureshdada Jain College of Pharmacy, Chandwad-423 101, Nashik, MS, India.
2NGSPM’s College of Pharmacy, Nashik, MS, India.

 

Cancer is the second leading cause of death in the western world. Despite advances in diagnosis and treatment, overall survival of patients remains poor. Scientific advances in recent years have enhanced our understanding of the biology of cancer. Human protein tyrosine kinases (PTKs) play a central role in human carcinogenesis and have emerged as the promising new targets. Several approaches to inhibit tyrosine kinase have been developed. These agents have shown impressive anticancer effects in preclinical studies and are emerging as promising agents in the clinic. The remarkable success of BCR-ABL tyrosine kinase inhibitor Imatinib (STI571) in the treatment of chronic myeloid leukaemia has particularly stimulated intense research in this field. In this review, we focus on the role of tyrosine kinases in cancer and the development of specific small molecule inhibitors for therapy. We also provide a critical analysis of the current data on epidermal growth factor receptor (EGFR) inhibitors and highlight areas for future research. Innovative approaches are needed to fully evaluate the potential of these agents, and a concerted international effort will hopefully help to integrate these inhibitors in cancer therapy in the near future.

Key words: Tyrosine kinase inhibitors, cancer, EGFR, EGF.
 

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Cite this article as:
Hitesh VS, Gokul ST (2018). EGFR: An important perspective in cancer therapy. Acad. J. Sci. Res. 6(11): 429-441.

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