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Research Article

Academia Journal of Scientific Research 3(1): 015-025, January 2015
DOI: 10.15413/ajsr.2014.0127
ISSN 2315-7712
2015 Academia Publishing




Splenic Size and Haematological Indices of Plasmodium Berghi Berghi Infected Mice Treated with Artesunate-Amodiaquine and Ciprofloxacin Combination


Accepted 25th December, 2014


*Uwah AF1, Ndem JI1 and Peter AI2
1Department of Biochemistry, Faculty of Basic Medical Sciences, University of Uyo, PMB 1017, Uyo, Akwa Ibom State, Nigeria.
2Department of Human Anatomy, Faculty of Basic Medical Sciences, University of Uyo, Akwa Ibom State, Nigeria.

*Corresponding author. E-mail: drtonyfideluwah@yahoo.com; drtonyfideluwah@gmail.com;
Tel: +2348038888814.


Haematological abnormalities are implicated in malaria and many pharmacologic agents used in the treatment of malaria in the tropics. The present study investigated the effects of Concomitant administration ACTs (artesunate-amodiaquine) with ciprofloxacin on splenic size and haematological indices of adult mice exposed Plasmodium berghei berghei. This triple regimen is commonly used in the treatment of febrile illnesses in our environment, the South-south region of Nigeria. Sixty (60) adult mice and Plasmodium berghei berghei were used in this investigation. The drugs were administered orally based on recommended therapeutic dosages of 4 mg/kg body weight of Artesunate, 10 mg/kg body weight of amodiaquine and 9 mg/kg body weight of ciprofloxacin in combination, ACT, and ciprofloxacin for 3 and 5 respectively. The results of this investigation showed remarkable alterations in haematological indices of untreated Plasmodium berghei berghei infected mice when compared with the normal control. Our findings indicate that treating P. berghei berghei infected mice with ACT only improves haematological indices more than ciprofloxacin only and ACT-ciprofloxacin combination. The weight and length of the spleen in experimental mice were significant ((P≤0.05) higher compared to the normal controls. All animals in the ACT only treatment group were observed to have recovered from the effect of P. berghei berghei as seen by the size and appearance of the spleen when compared with mice treated with ciprofloxacin only or ciprofloxacin plus ACT. Our findings suggest the need for haematoprotective agents along with the use of this triple regiment during and after treatment of malaria.

Key words: Artesunate-amodiaquine, ciprofloxacin, combination therapy, malaria, haematological indices, splenomegaly.


This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cite this article as:
Uwah AF, Ndem JI, Peter AI (2015). Splenic Size and Haematological Indices of Plasmodium Berghi Berghi Infected Mice Treated with Artesunate-Amodiaquine and Ciprofloxacin Combination. Acad. J. Sci. Res. 3(1): 015-025.

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