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Research Article

Academia Journal of Food Research 6(10): 069-075, October 2018
DOI: 10.15413/ajfr.2018.0105
ISSN 2315-7763
©2018 Academia Publishing



Omega-3 fatty acids, coenzyme Q10, vitamin E, -D3 and -B2: A powerful combination to reduce systolic-/diastolic blood pressure, lower heart rate and improve heart-rate-variability (Short report)



Accepted 13th October, 2018

Peter Lembke1* and Jürgen Vogelgesang2

1Zum Sudhaus 3, 66453 Gersheim, Germany.
2Johanner Str. 41-43, D-66111 Saarbrücken, Germany.


It is well known that a number of natural extracts show beneficial effects on elevated blood pressure. Among them are the two omega-3 fatty acids: EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid). To determine the effects of lowering blood pressure, most studies have shown the necessity to ingest at least 3 g EPA+DHA per day. This is a very large quantity, especially considering the fact that a normal fish oil only contains 25-30% EPA+DHA. As regards consumer compliance, this is not manageable over a prolonged time. The present study was conducted to determine if a specially composed omega-3 supplement softgel capsule with only 1.1 g EPA+DHA, fortified with CoQ10, vit-E, vit-D3 and vit- B2, could show similar blood pressure lowering effects than 3 g pure EPA+DHA per day. The pilot study was carried out with 11 healthy subjects between 32 and 73 years of age (5 men and 6 women) over a period of 8 weeks, who were asked to take 1 capsule of the omega-3 formulation per day. The blood pressure (systolic and diastolic), heart rate/pulse (relaxed) and heart rate variability (HRV) were measured on day 0 (baseline), after 4 weeks and 8 weeks. The average blood pressure (sys/dia) dropped from 142.8/93.5 to 138.1/90.8 mm Hg (4 weeks, p=0.028/0.046) and to 135.5/88.6 mm Hg after 8 weeks (p=0.016/0.024). It was observed a linear reduction of the average relaxed pulse from 72 beats (baseline), to 70 (4 weeks, p=0.06) and 68 beats per minute after 8 weeks (p=0.012). The average HRV increased from 35 ARI (Autonomic Regulation Index) at baseline to 37 ARI (4 weeks, p=0.005) and 43 ARI (8 weeks, p=0.00005). The results of this study show that by combining EPA+DHA with CoQ10, vit. E, vit D3 and vit. B2, it may be possible to achieve a similar or even superior blood pressure lowering effect with only 1.1 g, instead of 3 g EPA+DHA per day (recommended by EFSA). In the course of this study, it was also observed an improvement of heart rate/pulse and HRV, adding to the overall cardiovascular health of the subjects.

Key words: Omega-3, EPA, DHA, CoQ10, vitamin D3, vitamin E, vitamin B2, blood pressure, heart rate, heart rate variability.


This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Cite this article as:
Lembke P, Vogelgesang J (2018). Omega-3 fatty acids, coenzyme Q10, vitamin E, -D3 and -B2: A powerful combination to reduce systolic-/diastolic blood pressure, lower heart rate and improve heart-rate-variability (Short report). Acad. J. Food. 6(10): 069-075.

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