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Research Article

Academia Journal of Agricultural Research 5(9): 233-242, September 2017
DOI: 10.15413/ajsr.2017.0241
ISSN: 2315-7739
2017 Academia Publishing



A set of plant essential oils have antioxidant activity in ultraviolet B-irradiated epidermal keratinocytes by upregulating antioxidant and detoxifying enzymes

Accepted 28th August, 2017

Jin Wook Jung1, Mei Shan Piao1, Jee-Young Choi1, Egyung Park2, Sook Jung Yun1, Jee-Bum Lee1 and Seung-Chul Lee1*

1Department of Dermatology, Chonnam National University Medical School, Jaebong-Ro, Gwnagju 501-757, Korea.
2Hisol co., Ltd, Baraebong-gil, Unbong-eup, Namwon-si, Jellobuk-do, Korea.


Plant-derived extracts including essential oils have long been used as important ingredients of cosmetics. In recent years, there has been a demand for safe cosmeceuticals with excellent anti-aging activity. This study aimed to develop candidate plant extracts with excellent antioxidant and detoxifying activities in keratinocytes with a view to protecting photo-aging of the skin. The ROS-scavenging activities of candidate plant essential oils were determined in ultraviolet B (UVB)-irradiated normal human epidermal keratinocytes (NHEKs). Their antioxidant and detoxifying activities were determined by measuring enzymatic antioxidants, phase 2 enzymes and total polyphenol content. In DCF-DA and confocal microscopy studies, the plant essential oils including Lavender oil, Lemongrass oil, Rosemary oil, Chamomile oil and Peppermint oil showed excellent ROS-scavenging activity in UVB-irradiated NHEKs. In RT-PCR studies, all these oils upregulated the expression of enzymatic antioxidants (CuSOD, GPx II and Prx I) and phase 2 detoxifying enzymes (HO-1, NQO-1, GSTpi, GSTA4, and GCLM)via Nrf2 in NHEKs. All of the five essential oils can be regarded as good candidate natural products with potential for use as new cosmeceuticals.

: Plant-derived extracts, cosmeceuticals, keratinocytes, photo-aging, skin.

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Cite this article as:

Jung JW, Piao MS, Choi JY, Park E, Yun SJ, Lee JB, Lee SC (2017). A set of plant essential oils have antioxidant activity in ultraviolet B-irradiated epidermal keratinocytes by upregulating antioxidant and detoxifying enzymes. Acad. J. Agric. Res. 5(9): 233-242

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